標題: SPRING: a tool for the analysis of genome rearrangement using reversals and block-interchanges
作者: Lin, Ying Chih
Lu, Chin Lung
Liu, Ying-Chuan
Tang, Chuan Yi
生物科技學系
Department of Biological Science and Technology
公開日期: 1-Jul-2006
摘要: SPRING( http://algorithm.cs.nthu.edu.tw/tools/SPRING/)is a tool for the analysis of genome rearrangement between two chromosomal genomes using reversals and/ or block- interchanges. SPRING takes two ormore chromosomes as its input and then computes a minimum series of reversals and/ or block-interchanges between any two input chromosomes for transforming one chromosome into another. The input of SPRING can be either bacterial- size sequences or gene/ landmark orders. If the input is a set of chromosomal sequences then the SPRING will automatically search for identical landmarks, which are homologous/ conserved regions shared by all input sequences. In particular, SPRING also computes the breakpoint distance between any pair of two chromosomes, which can be used to compare with the rearrangement distance to confirm whether they are correlated or not. In addition, SPRING shows phylogenetic trees that are reconstructed based on the rearrangement and breakpoint distance matrixes.
URI: http://dx.doi.org/10.1093/nar/gkl169
http://hdl.handle.net/11536/12070
ISSN: 0305-1048
DOI: 10.1093/nar/gkl169
期刊: NUCLEIC ACIDS RESEARCH
Volume: 34
Issue: 
起始頁: W696
結束頁: W699
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