標題: RegRNA: an integrated web server for identifying regulatory RNA motifs and elements
作者: Huang, Hsi-Yuan
Chien, Chia-Hung
Jen, Kuan-Hua
Huang, Hsien-Da
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 1-Jul-2006
摘要: Numerous regulatory structural motifs have been identified as playing essential roles in transcriptional and post- transcriptional regulation of gene expression. RegRNA is an integrated web server for identifying the homologs of regulatory RNA motifs and elements against an input mRNA sequence. Both sequence homologs and structural homologs of regulatory RNA motifs can be recognized. The regulatory RNA motifs supported in RegRNA are categorized into several classes: ( i) motifs in mRNA 50- untranslated region ( 50- UTR) and 30- UTR; ( ii) motifs involved in mRNA splicing; ( iii) motifs involved in transcriptional regulation; ( iv) riboswitches; ( v) splicing donor/ acceptor sites; ( vi) inverted repeats; and ( vii) miRNA target sites. The experimentally validated regulatory RNA motifs are extracted from literature survey and several regulatory RNA motif databases, such as UTRdb, TRANSFAC, alternative splicing database ( ASD) and miRBase. A variety of computational programs are integrated for identifying the homologs of the regulatory RNA motifs. An intuitive user interface is designed to facilitate the comprehensive annotation of user-submitted mRNA sequences. The RegRNA web server is now available at http://RegRNA.mbc.NCTU.edu.tw/.
URI: http://dx.doi.org/10.1093/nar/gkl333
http://hdl.handle.net/11536/12069
ISSN: 0305-1048
DOI: 10.1093/nar/gkl333
期刊: NUCLEIC ACIDS RESEARCH
Volume: 34
Issue: 
起始頁: W429
結束頁: W434
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