Title: Codon-usage bias versus gene conversion in the evolution of yeast duplicate genes
Authors: Lin, Yeong-Shin
Byrnes, Jake K.
Hwang, Jenn-Kang
Li, Wen-Hsiung
生物科技學系
Department of Biological Science and Technology
Keywords: selective constraints;whole-genome duplication;concerted evolution;decelerated evolution
Issue Date: 26-Sep-2006
Abstract: Many Saccharomyces cerevisiae duplicate genes that were derived from an ancient whole-genome duplication (WGD) unexpectedly show a small synonymous divergence (K-S), a higher sequence similarity to each other than to orthologues in Saccharomyces bayanus, or slow evolution compared with the orthologue in Kluyveromyces waltii, a non-WGD species. This decelerated evolution was attributed to gene conversion between duplicates. Using approximate to 300 WGD gene pairs in four species and their orthologues in non-WGD species, we show that codon-usage bias and protein-sequence conservation are two important causes for decelerated evolution of duplicate genes, whereas gene conversion is effective only in the presence of strong codon-usage bias or protein-sequence conservation. Furthermore, we find that change in mutation pattern or in tDNA copy number changed codon-usage bias and increased the K-S distance between K. waltii and S. cerevisiae. Intriguingly, some proteins showed fast evolution before the radiation of WGD species but little or no sequence divergence between orthologues and paralogues thereafter, indicating that functional conservation after the radiation may also be responsible for decelerated evolution in duplicates.
URI: http://dx.doi.org/10.1073/pnas.0606348103
http://hdl.handle.net/11536/11758
ISSN: 0027-8424
DOI: 10.1073/pnas.0606348103
Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume: 103
Issue: 39
Begin Page: 14412
End Page: 14416
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