標題: ViTa: prediction of host microRNAs targets on viruses
作者: Hsu, Paul Wei-Che
Lin, Li-Zen
Hsu, Sheng-Da
Hsu, Justin Bo-Kai
Huang, Hsien-Da
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 1-Jan-2007
摘要: MicroRNAs (miRNAs) are involved in various biological processes by suppressing gene expression. A recent work has indicated that host miRNAs are also capable of regulating viral gene expression by targeting the virus genomes. To investigate regulatory relationships between host miRNAs and related viruses, we present a novel database, namely ViTa, to curate the known virus miRNA genes and the known/putative target sites of human, mice, rat and chicken miRNAs. Known miRNAs are obtained from miRBase. Virus data are collected and referred from ICTVdB, VBRC and VirGen. Experimentally validated miRNA targets on viruses were derived from literatures. Then, miRanda and TargetScan are utilized to predict miRNA targets within virus genomes. ViTa also provides the virus annotations, virus-infected tissues and tissue specificity of host miRNAs. This work also facilitates the comparisons between subtypes of viruses, such as influenza viruses, human liver viruses and the conserved regions between viruses. Both textual and graphical web interfaces are provided to facilitate the data retrieves in the ViTa database. The database is now freely available at http://vita.mbc.nctu.edu.tw/.
URI: http://dx.doi.org/10.1093/nar/gkl1009
http://hdl.handle.net/11536/11292
ISSN: 0305-1048
DOI: 10.1093/nar/gkl1009
期刊: NUCLEIC ACIDS RESEARCH
Volume: 35
Issue: 
起始頁: D381
結束頁: D385
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