標題: Kappa-alpha plot derived structural alphabet and BLOSUM-like substitution matrix for rapid search of protein structure database
作者: Tung, Chi-Hua
Huang, Jhang-Wei
Yang, Jinn-Moon
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 2007
摘要: We present a novel protein structure database search tool, 3D- BLAST, that is useful for analyzing novel structures and can return a ranked list of alignments. This tool has the features of BLAST ( for example, robust statistical basis, and effective and reliable search capabilities) and employs a kappa-alpha (kappa, alpha) plot derived structural alphabet and a new substitution matrix. 3D- BLAST searches more than 12,000 protein structures in 1.2 s and yields good results in zones with low sequence similarity.
URI: http://hdl.handle.net/11536/11253
http://dx.doi.org/10.1186/gb-2007-8-3-r31
ISSN: 1474-760X
DOI: 10.1186/gb-2007-8-3-r31
期刊: GENOME BIOLOGY
Volume: 8
Issue: 3
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