標題: The effect of centaurein on interferon-gamma expression and Listeria infection in mice
作者: Chang, Shu-Lin
Yeh, Hsu-Hua
Lin, Yu-Shiun
Chiang, Yi-Ming
Wu, Tung-Kung
Yang, Wen-Chin
生物科技學系
Department of Biological Science and Technology
關鍵字: centaurein;IFN-gamma;Listeria;flavonoid
公開日期: 15-二月-2007
摘要: We previously found that centaurein enhanced IFN-gamma transcription in T cells. Here, we demonstrate that centaurein increased the IFN-gamma expression in T and NK cells and the serum IFN-gamma level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-gamma but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-gamma expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-gamma expression. (c) 2006 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.taap.2006.11.026
http://hdl.handle.net/11536/11128
ISSN: 0041-008X
DOI: 10.1016/j.taap.2006.11.026
期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume: 219
Issue: 1
起始頁: 54
結束頁: 61
顯示於類別:期刊論文


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