Title: Preparation and characterization of thermal-sensitive ferrofluids for drug delivery application
Authors: Liu, Ting-Yu
Hu, Shang-Hsiu
Hu, Sheng-Hsiang
Tsai, Szu-Ping
Chen, San-Yuan
Department of Materials Science and Engineering
Keywords: ferrofluid;core shell;magnetic nanoparticle;pluronic F127;thermal sensitive;drug delivery
Issue Date: 1-Mar-2007
Abstract: Novel thermal-sensitive ferro fluids (F127-ferro fluids) consisting of core-shell-type magnetic nanoparticles dispersed in Pluronic F127-containing aqueous solution were prepared. The core (magnet)-shell (Pluronic F127) nanoparticles were synthesized by in situ coprecipitation process, which were characterized using transmission electron microscope, X-ray diffraction and vibrating sample magnetometer. The F127-ferro fluids gelled above the lower critical solution temperatures (LCST) of approximately 23-28 degrees C, which were higher than that of pure Pluronic F127-. fluids ( 21-25 degrees C). The increase in the LCST of the F127 ferro. fluids may be attributed to a result of a physical interaction between the F127 molecules and the core-shell magnetic nanoparticles. (C) 2006 Elsevier B. V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jmmm.2006.11.129
ISSN: 0304-8853
DOI: 10.1016/j.jmmm.2006.11.129
Volume: 310
Issue: 2
Begin Page: 2850
End Page: 2852
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