標題: Proportion of solvent-exposed amino acids in a protein and rate of protein evolution
作者: Lin, Yeong-Shin
Hsu, Wei-Lun
Hwang, Jenn-Kang
Li, Wen-Hsiung
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
關鍵字: evolutionary rate;protein structure;fitness density;functional density;solvent accessibility;disordered
公開日期: 1-Apr-2007
摘要: Translational selection, including gene expression, protein abundance, and codon usage bias, has been suggested as the single dominant determinant of protein evolutionary rate in yeast. Here, we show that protein structure is also an important determinant. Buried residues, which are responsible for maintaining protein structure or are located on a stable interaction surface between 2 subunits, are usually under stronger evolutionary constraints than solvent-exposed residues. Our partial correlation analysis shows that, when whole proteins are included, the variance of evolutionary rate explained by the proportion of solvent-exposed residues (P-exposed) can reach two-thirds of that explained by translational selection, indicating that P-exposed is the most important determinant of protein evolutionary rate next only to translational selection. Our result suggests that proteins with many residues under selective constraint (e.g., maintaining structure or intermolecular interaction) tend to evolve slowly, supporting the "fitness (functional) density" hypothesis.
URI: http://dx.doi.org/10.1093/molbev/msm019
http://hdl.handle.net/11536/10975
ISSN: 0737-4038
DOI: 10.1093/molbev/msm019
期刊: MOLECULAR BIOLOGY AND EVOLUTION
Volume: 24
Issue: 4
起始頁: 1005
結束頁: 1011
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