標題: Direct and in vitro observation of growth hormone receptor molecules in A549 human lung epithelial cells by nanodiamond labeling
作者: Cheng, C.-Y.
Perevedentseva, E.
Tu, J.-S.
Chung, P.-H.
Cheng, C.-L.
Liu, K.-K.
Chao, J.-I.
Chen, P.-H.
Chang, C.-C.
生物科技學系
Department of Biological Science and Technology
公開日期: 16-Apr-2007
摘要: This letter presents direct observation of growth hormone receptor in one single cancer cell using nanodiamond-growth hormone complex as a specific probe. The interaction of surface growth hormone receptor of A549 human lung epithelial cells with growth hormone was observed using nanodiamond's unique spectroscopic signal via confocal Raman mapping. The growth hormone molecules were covalent conjugated to 100 nm diameter carboxylated nanodiamonds, which can be recognized specifically by the growth hormone receptors of A549 cell. The Raman spectroscopic signal of diamond provides direct and in vitro observation of growth hormone receptors in physiology condition in a single cell level. (C) 2007 American Institute of Physics.
URI: http://dx.doi.org/10.1063/1.2727557
http://hdl.handle.net/11536/10893
ISSN: 0003-6951
DOI: 10.1063/1.2727557
期刊: APPLIED PHYSICS LETTERS
Volume: 90
Issue: 16
結束頁: 
Appears in Collections:Articles


Files in This Item:

  1. 000245870400135.pdf