標題: pKNOT: the protein KNOT web server
作者: Lai, Yan-Long
Yen, Shih-Chung
Yu, Sung-Huan
Hwang, Jenn-Kang
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
公開日期: 1-七月-2007
摘要: Knotted proteins are more commonly observed in recent years due to the enormously growing number of structures in the Protein Data Bank (PDB). Studies show that the knot regions contribute to both ligand binding and enzyme activity in proteins such as the chromophore-binding domain of phytochrome, ketol-acid reductoisomerase or SpoU methyltransferase. However, there are still many misidentified knots published in the literature due to the absence of a convenient web tool available to the general biologists. Here, we present the first web server to detect the knots in proteins as well as provide information on knotted proteins in PDB-the protein KNOT (pKNOT) web server. In pKNOT, users can either input PDB ID or upload protein coordinates in the PDB format. The pKNOT web server will detect the knots in the protein using the Taylor's smoothing algorithm. All the detected knots can be visually inspected using a Java-based 3D graphics viewer. We believe that the pKNOT web server will be useful to both biologists in general and structural biologists in particular.
URI: http://dx.doi.org/10.1093/nar/gkm304
http://hdl.handle.net/11536/10617
ISSN: 0305-1048
DOI: 10.1093/nar/gkm304
期刊: NUCLEIC ACIDS RESEARCH
Volume: 35
Issue: 
起始頁: W420
結束頁: W424
顯示於類別:期刊論文


文件中的檔案:

  1. 000255311500079.pdf