標題: Angiotensin I-Converting enzyme insertion-related genotypes and allele are associated with higher susceptibility of endometriosis and leiomyoma
作者: Hsieh, Yao-Yuan
Lee, Cheng-Chun
Chang, Chi-Chen
Wang, Yu-Kuo
Yeh, Lian-Shun
Lin, Chich-Sheng
生物科技學系
Department of Biological Science and Technology
關鍵字: angiotensin I-converting enzyme;ACE;endometriosis;leiomyoma;polymorphism
公開日期: 1-Jul-2007
摘要: Endometriosis and leiomyoma display features similar to malignancy, requiring neovascularization to proliferation and growth. Altered vascular-related genes might be related to the development of endometriosis and leiomyoma. Polymorphisms of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) genes have been linked with some vascular diseases. This study investigates whether ACE I/D gene polymorphisms could be used as markers of susceptibility in endometriosis and leiomyoma. Women were divided into three groups: (4) endometriosis (n = 125); (2) leiomyoma (n = 120); () normal controls (n = 128). Genomic DNA was obtained from peripheral leukocyte. ACE I/D gene polymorphisms in intron 16 were amplified by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) Genotypes and allelic frequencies in both groups were compared. We observed the genotype distribution and allele frequency of ACE I/ D gene polymorphisms in both groups were significantly different. Proportions of ACE(star)I homozygote/ heterozygote/D homozygote in both groups were: (1) 50.4/24/25.6%; (2) 25/23.33/51.67%; (3) 10.2/ 29.7/60.1%. Proportions of I/D alleles in each group Were: (1) 62.4/37.6%; (2) 36.7/63.3%; (3) 25/75%. We concluded that ACE(star)I/D gene polymorphisms are associated with endometriosis and leiomyoma suspeptibilities. ACE(star)I-related genotypes and allele are strongly related to the occurrence of endometriosis and moderately related to the occurrence of leiomyoma.
URI: http://dx.doi.org/10.1002/mrd.20474
http://hdl.handle.net/11536/10581
ISSN: 1040-452X
DOI: 10.1002/mrd.20474
期刊: MOLECULAR REPRODUCTION AND DEVELOPMENT
Volume: 74
Issue: 7
起始頁: 808
結束頁: 814
Appears in Collections:Articles


Files in This Item:

  1. 000246889800002.pdf