標題: Calcium alginate microcapsule generation on a microfluidic system fabricated using the optical disk process
作者: Huang, Keng-Shiang
Liu, Ming-Kai
Wu, Chun-Han
Yen, Yu-Tang
Lin, Yu-Cheng
機械工程學系
Department of Mechanical Engineering
公開日期: 1-八月-2007
摘要: This paper describes the generation of monodisperse calcium alginate (Ca-alginate) microcapsules on a microfluidic platform using the commercial optical disk process. Our strategy is based on combining the rapid injection molding process for a cross-junction microchannel with the sheath focusing effect to form uniform water-in-oil (w/o) emulsions. These emulsions, consisting of 1.5% (w/v) sodium alginate (Na-alginate), are then dripped into a solution containing 20% (w/v) calcium chloride (CaCl2) creating Ca-alginate microparticles in an efficient manner. This paper demonstrates that the size of Ca-alginate microparticles can be controlled from 20 mu m to 50 mu m in diameter with a variation of less than 10%, simply by altering the relative sheath/sample flow rate ratio. Experimental data show that for a given fixed dispersed phase flow (sample flow), the emulsion size decreases as the average flow rate of the continuous phase flow (sheath flow) increases. The proposed microfluidic platform is capable of generating relatively uniform emulsions and has the advantages of active control of the emulsion diameter, a simple and low cost process and a high throughput.
URI: http://dx.doi.org/10.1088/0960-1317/17/8/003
http://hdl.handle.net/11536/10504
ISSN: 0960-1317
DOI: 10.1088/0960-1317/17/8/003
期刊: JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Volume: 17
Issue: 8
起始頁: 1428
結束頁: 1434
顯示於類別:期刊論文


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