Synthesis and Characterization of Inorganically-Modified Amphiphilic Chitosan-Based Hybrid and Its Potentials for Biomedical Uses
|關鍵字:||本質幾丁聚醣;羧甲基酸-己醯基幾丁聚醣;兩性幾丁聚醣;無機幾丁聚醣複合物;自組裝;藥物釋放;溶膠凝膠化學;膠體穩定性;奈米結構;奈米載體;磁控制藥物釋放;奈米影像;native chitosan;carboxymethyl-hexanoyl chitosan (CHC);amphiphlicchitosan;inorganic-bearing chitosan hybrid;self-assembly;drug delivery;sol-gelchemistry;colloidal stability;nanostructure;nanocapsule;magnetic control drugrelease;nanoimaging|
Chitosan, a linear polysaccharide, has been well-known as a natural polymer for numerous applications from medicine, pharmaceutics, chemical separation, to environmental engineering. However, its poor solvency in neutral media and solvents limited its potential applications, even though it has exhibited biocompatibility, non-toxicity, and biodegradability. With the advancement of synthetic chemistry, hydrophobic modification with organic moieties has been employed to form amphiphilic counterpart and has been received great attentions, as for instance, drug carrier and scaffold for tissue engineering. Incorporation of inorganic component into chitosan molecule has recently been studied and has received increasingly attentions over the disciplines from synthetic chemistry, materials chemistry, colloidal science, medicine, and biotechnology, since it has recognized to integrate merits from inorganic and organic counterparts of the resulting hybrids, to further boost desirable properties with enhanced performance. Recently, a dual-ligand modification using hydrophilic carboxymethyl and hydrophobic hexanoyl pedants along the backbone of native chitosan, has been successfully synthesized in our lab and has giving a novel amphiphilc chitosan, termed as CHC, capable of self-assembling from dense nanoparticle to hollow nanocapsules with controllable size and hydrophobicity. They also showed a diverse ability for encapsulating therapeutic agents of various chemical affinity. However, it is more technically desirable and scientifically sound by taking the advantages of inorganic moieties with additional functionalities to the resulting hybrid, and this turns out to be the central issue of this research proposal, where we intend to further move this CHC molecule a step ahead by intramolecular modification with inorganic ligands, such as silanes and iron oxide, and according to our recent preliminary observation, a new class of amphiphilic inorganic-bearing CHC hybrid molecule with unprecedentedly sub-nano morphological structure can be obtained. It is highly anticipated that such an inorganic-bearing CHC molecular hybrid should exhibit new properties that may not be explored before and this research work should pave a new avenue to provide both scientific and technical advantages based on an in-depth understanding the chemical, physical, and biomedical fundamentals of this new hybrid system, associated with its potential (bio)technical applications.
|Appears in Collections:||Research Plans|
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